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Which type of bioreactor is most suitable for the production of monoclonal antibodies that require strict control of shear stress?

medium MCQ 2 marks Class 12 · Biology · Biotechnology Principles and Processes
  1. Stirred‑tank bioreactor
  2. Air‑lift bioreactor
  3. Packed‑bed reactor
  4. Bubble column reactor
Answer
Air‑lift bioreactor

The correct answer is Air‑lift bioreactor — Select the air‑lift bioreactor as the most appropriate choice.

Step-by-step solution

  1. Identify that monoclonal antibody‑producing mammalian cells are shear‑sensitive.
  2. Recall that air‑lift bioreactors provide mixing by circulation of gas‑lifted bubbles and generate much lower shear forces than mechanically stirred vessels.
  3. Compare the listed options: stirred‑tank (high shear), packed‑bed (used for immobilised cells), bubble column (moderate shear), air‑lift (low shear).
  4. Select the air‑lift bioreactor as the most appropriate choice.
Common mistake: Choosing a stirred‑tank bioreactor because it is the most common type, ignoring its higher shear environment

Concept tested: Bioreactor selection for low‑shear cultures

Published · How this solution was prepared and checked

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