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A female who carries the allele for haemophilia (X^h X^+) is crossed with a normal male (X^+ Y). Which of the following gives the correct phenotypic ratio of male offspring?

easy MCQ 2 marks Class 12 · Biology · Principles of Inheritance and Variation
  1. 0 affected : 1 normal
  2. 1 affected : 1 normal
  3. 1 affected : 2 normal
  4. 1 affected : 3 normal
Answer
1 affected : 1 normal

The correct answer is 1 affected : 1 normal — The phenotypic ratio of affected : normal among sons is therefore 1 : 1.

Step-by-step solution

  1. Male offspring inherit their single X chromosome from the mother and the Y chromosome from the father.
  2. The mother can transmit either X^h or X^+ with equal probability (½ each).
  3. Hence, ½ of the sons receive X^h and are affected, while ½ receive X^+ and are normal.
  4. The phenotypic ratio of affected : normal among sons is therefore 1 : 1.
Common mistake: Assuming sons inherit both alleles from mother

Concept tested: X‑linked inheritance

Published · How this solution was prepared and checked

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