A female who carries the allele for haemophilia (X^h X^+) is crossed with a normal male (X^+ Y). Which of the following gives the correct phenotypic ratio of male offspring?
Answer
1 affected : 1 normal
The correct answer is 1 affected : 1 normal — The phenotypic ratio of affected : normal among sons is therefore 1 : 1.
Step-by-step solution
- Male offspring inherit their single X chromosome from the mother and the Y chromosome from the father.
- The mother can transmit either X^h or X^+ with equal probability (½ each).
- Hence, ½ of the sons receive X^h and are affected, while ½ receive X^+ and are normal.
- The phenotypic ratio of affected : normal among sons is therefore 1 : 1.
Common mistake: Assuming sons inherit both alleles from mother
Concept tested: X‑linked inheritance
Published · How this solution was prepared and checked
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